Letrozole is a medication commonly used in the treatment of hormone receptor-positive breast cancer and sometimes for fertility purposes. Its effectiveness hinges on its specific mode of action, which involves altering hormonal pathways within the body.
How Letrozole Works at the Molecular Level
The Role of Aromatase Enzyme
Letrozole functions primarily by https://letrozolebuy.com/prod/letrozol-teva-filmtabletten-2-5mg-100-stuck/ inhibiting the enzyme aromatase. Aromatase is responsible for converting androgens, such as testosterone and androstenedione, into estrogens like estradiol and estrone. This conversion is a key step in estrogen biosynthesis, especially in postmenopausal women where peripheral tissues are the main source of estrogen.
Inhibition of Estrogen Production
By blocking aromatase activity, letrozole effectively reduces estrogen levels in the bloodstream. Since many breast cancers grow in response to estrogen, decreasing its availability can slow or stop tumor progression.
Implications of the Letrozole Mode of Action
Treatment of Breast Cancer
In hormone receptor-positive breast cancer, letrozole‘s ability to suppress estrogen production makes it a potent endocrine therapy option. It is particularly effective in postmenopausal women, where ovarian estrogen synthesis is minimal, and peripheral conversion is predominant.
Use in Fertility Treatments
Additionally, letrozole is used off-label to induce ovulation in women facing infertility issues. By lowering estrogen levels, it stimulates the hypothalamus and pituitary gland to increase gonadotropin secretion, promoting follicular development.
Summary of the Letrozole Mode of Action
In essence, letrozole exerts its therapeutic effects through targeted inhibition of aromatase, leading to decreased estrogen synthesis. This mechanism underpins its application in breast cancer management and fertility treatments, highlighting its significance in hormonal therapies.